Faxofer 40 Dosage/Direction for Use

For treatment of hyperuricemia in patients with gout, FAXOFER 40 is recommended at 40 mg or 80 mg once daily.
The recommended starting dose of FAXOFER 40 is 40 mg once daily. For patients who do not achieve a serum uric acid (sUA) less than 6 mg per dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended.
FAXOFER 40 can be taken without regard to food or antacid use.
Special Populations: No dose adjustment is necessary when administering Febuxostat in patients with mild to moderate renal impairment.
The recommended starting dose of Febuxostat is 40 mg once daily. For patients who do not achieve a sUA less than 6 mg per dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended. No dose adjustment is necessary in patients with mild to moderate hepatic impairment.
Uric Acid Level: Testing for the target serum uric acid level of less than 6 mg per dL may be performed as early as 2 weeks after initiating Febuxostat therapy.
Gout Flares: Gout flares may occur after initiation of Febuxostat due to changing serum uric acid levels resulting in mobilization of urate from tissue deposits. Flare prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended upon initiation of Febuxostat. Prophylactic therapy may be beneficial for up to six months.
If a gout flare occurs during Febuxostat treatment, Febuxostat need not be discontinued. The gout flare should be managed concurrently, as appropriate for the individual patient.